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Major- and Trace-Element Concentrationsin Soils from Two Continental-Scale Transects of the UnitedStates and Canada. Modification and mutation ofspecific groups of normal cellular genes, Proto-Oncogenesand Tumor-Suppressor genes, are important in the tumorformation and can be targeted by chemicals and radiation.The development and progression of cancer, like all chronicdiseases, involves gene–environment interaction. Spinal tuberculosis: a diagnostic andmanagement challenge.
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Patsopoulos (2011), for instance, discusses thedistinction between an explanatory trial that—concerned primarily with issues of internalvalidity—addresses questions of treatment efficacy and a pragmatic trial that—concernedprimarily with issues of external validity—answers questions of treatment effective-ness. Campbell and Stanley (1966) define the instrumentation threat tointernal validity as one “in which changes in the calibration of a measuring instrument orchanges in the observers or scorers used may produce changes in the obtained measure-ments” (p.
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